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《医学前沿(英文)》 2016年 第10卷 第4期 页码 444-450 doi: 10.1007/s11684-016-0471-x
The incidence rate of pancreatic neuroendocrine neoplasms (pNENs) has increased rapidly in recent years. However, the clinicopathological characteristics of pNENs are poorly understood. Medical records of patients who underwent surgery and were confirmed as pNENs by pathological examination from January 2003 to February 2015 in Qilu Hospital were reviewed retrospectively. A total of 100 patients, 36 males and 64 females, were included with a mean operation age of 46.26±13.41 years. Among the 100 cases, 76 had insulinomas and 24 had non-functional pNENs. Tumor size ranged from 0.5 cm to 9 cm, and the mean size was 2.20±1.40 cm. The percentages of TNM stages I, II, III, and IV tumors were 89.0%, 8.0%, 0.0%, and 3.0%, respectively. Based on the WHO classification, pNENs were classified into three grades: G1, G2, and G3. G1, G2, and G3 tumors were confirmed in 72.9%, 23.7%, and 3.4% patients, respectively. The positive rates of CgA and Syn immunohistochemical staining were 94.5% (69/73) and 100% (74/74), respectively. Compared with insulinoma, non-functional pNENs have larger tumor sizes, more advanced TNM staging, a higher Ki-67 index, and a higher rate of liver metastasis (P<0.05). In conclusion, pNENs are heterogeneous tumors with varying clinical manifestations, diverse tumor biological characteristics, and different prognoses. Non-functional pNENs present a more aggressive behavioral model and have poorer prognosis than functional pNENs.
关键词: pancreatic neuroendocrine neoplasms clinicopathological characteristic Ki-67 liver metastasis outcomes
《医学前沿(英文)》 页码 907-923 doi: 10.1007/s11684-023-1009-7
The clinicopathologic features of intraductal papillary mucinous neoplasms of the pancreas
QIN Xinyu, LIU Fenglin
《医学前沿(英文)》 2007年 第1卷 第2期 页码 121-125 doi: 10.1007/s11684-007-0023-5
关键词: available additional existence necessitate intraductal papillary non-invasive
A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy
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《医学前沿(英文)》 2015年 第9卷 第1期 页码 112-116 doi: 10.1007/s11684-014-0345-z
Primary neuroendocrine breast carcinoma (NEBC) is a very rare type of breast cancer. Two characteristic biomarkers, namely, CgA and Syn, should be immunohistochemically detected to diagnose NEBC. In this study, a 43-year-old woman with a large mass of 8.3 cm × 2.9 cm in her right breast was reported. The patient was pathologically diagnosed with NEBC after specific markers, including CgA and Syn, as well as few differential markers, such as CK7, ER, PR, C-erbB-2, NSE, and E-cadherin, were immunohistochemically detected. The patient showed a remarkable response to four cycles of neo-adjuvant chemotherapy (partial response based on RECIST criteria) and sequentially underwent modified radical mastectomy. Moreover, the diagnosis and treatment of NEBC based on this case and available related literature were discussed.d literature were discussed.
Small cell carcinoma of the urinary bladder without gross hematuria: a case report
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《医学前沿(英文)》 2015年 第9卷 第3期 页码 384-387 doi: 10.1007/s11684-015-0405-z
Small cell carcinoma of the urinary bladder (SCCB) is a rare and aggressive form of bladder cancer with poor prognosis. Hematuria is the main symptom of this malignancy, and most patients have a history of smoking. The disease incidence of malignant bladder tumors in China is approximately 0.74%. Early and accurate diagnosis of SCCB can ensure timely and appropriate treatment of this malignant disease. Oncologic surgery is the standard treatment; however, it may not be a curative approach. Chemotherapy and/or radiotherapy should be performed following surgical removal. This case report describes a patient with a single neoplasm diagnosed as SCCB that arose because of recurrence of bladder cancer after bladder tumor resection. In contrast to previously reported cases, this patient had no gross hematuria and no history of smoking.
关键词: carcinoma small cell urinary bladder neoplasms diagnosis
《医学前沿(英文)》 2022年 第16卷 第3期 页码 403-415 doi: 10.1007/s11684-021-0858-1
关键词: myeloproliferative neoplasms IRF4 IRF8 hydroxyurea essential thrombocythemia
Mechanisms of “kidney governing bones” theory in traditional Chinese medicine
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《医学前沿(英文)》 2014年 第8卷 第3期 页码 389-393 doi: 10.1007/s11684-014-0362-y
Studies conducted by our group on the mechanism of “kidney governing bones” theory in traditional Chinese medicine (TCM) are reviewed in this paper. Conclusions can be summarized as follows. (1) Neuroendocrine-immune network (NIN)-osteoclast regulatory pathway OPG-RANKL-RANK is one of the mechanisms of “kidney governing bones.” Although kidney-reinforcing therapy is regarded as one of the holistic regulatory mechanisms of the body, characteristic holistic regulation in TCM can be reflected through nonselective regulation of the NIN during kidney reinforcement therapy, which can be used to treat osteoporosis through microadjustments in the microenvironment of the bone marrow. (2) Marrow exhaustion in TCM, which is the state wherein lipocytes in the bone marrow increase whereas other cells decrease, serves as the pathogenesis of osteoporosis brought about by failure of the “kidney governing bones.” (3) The kidney in TCM can be regarded as a complex system comprising multiple functional units in the body, including the unit “governing bones.” Kidney deficiency refers to a deficiency in only one or more units of the kidney system and not the whole system itself, which explains the kidney-reinforcing effect of many herbs; some herbs can treat osteoporosis, but some cannot. Although both classified as kidney-reinforcing agents, the former can resolve failure of the “kidney governing bones” unit while the latter regulates the failure of other units in the kidney system. Despite the current understanding on “kidney governing bones” theory, the mechanism of “kidney governing bones” remains complicated and unresolved. Thus, further studies in this area are warranted.
关键词: kidney governing bones kidney deficiency marrow osteoporosis neuroendocrine-immune network osteoclast regulatory pathway
Expression of PC-cell-derived growth factor in breast cancer
Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 426-430 doi: 10.1007/s11684-009-0085-7
关键词: PC-cell-derived growth factor breast neoplasms clinical markers
Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma
Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 430-435 doi: 10.1007/s11684-010-0700-7
唐孝威,沈小雷,何宏建
《中国工程科学》 2008年 第10卷 第11期 页码 14-17
在考察针刺穴位治疗作用的基础上,根据现有的实验事实,将人体经络的观念和经改进后的神经-内分泌-免疫系统的观念统一起来,提出人体经络是具有敏感节点和功能连接的神经-内分泌-免疫网络的假说。人体经络的复杂网络不仅是遍及全身的系统,而且可以通过敏感节点及其功能连接对身体起调控作用。
关键词: 人体经络 针刺穴位 神经-内分泌-免疫系统 复杂网络
标题 作者 时间 类型 操作
Analysis of 100 consecutive cases of resectable pancreatic neuroendocrine neoplasms: clinicopathological
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期刊论文
High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas
期刊论文
The clinicopathologic features of intraductal papillary mucinous neoplasms of the pancreas
QIN Xinyu, LIU Fenglin
期刊论文
A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy
null
期刊论文
IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential thrombocythemia
期刊论文
Expression of PC-cell-derived growth factor in breast cancer
Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,
期刊论文
Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma
Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,
期刊论文